Henry Ruggs' NFL career is likely over ... so says Shannon Sharpe, who tells TMZ Sports he believes the former Raiders star's fatal car crash will "probably" cost him his spot in the league.

The Hall of Famer broke it down at LAX earlier this week ... saying he's pretty sure Ruggs' alleged actions during the Nov. 2 wreck in Las Vegas will almost certainly spell the end of his time as an NFL player.

"It's sad," the Broncos legend said. "I hate it for him that what he's going to have to go through probably cost himself a career."

Sharpe, though, made it clear he doesn't have too much sympathy for the 22-year-old over it all ... explaining the choices Ruggs is accused of making that night are just inexcusable.