Shannon Sharpe has heard enough from Drew Brees -- and he's sick of it -- calling for the QB to retire and walk away already.

The NFL Hall of Famer went off on Drew on FS1's 'Undisputed' -- calling Drew's apology "meaningless" and explaining why he'll never respect Brees again.

"He issued an apology, Skip, but it's meaningless because the guys know he spoke his heart the very first time around."

"I don't know what Drew's going to do, but he probably should just go ahead and retire now. He will never be the same."