Already sidelined by a high ankle sprain, San Francisco 49ers cornerback K'Waun Williams will miss at least the next two games after the NFL suspended him Tuesday for violating the league's policy on performance-enhancing substances.

The earliest Williams can return from the two-game suspension is Tuesday, Dec. 8, after the Niners play the Buffalo Bills on Monday Night Football.

Jamar Taylor has handled slot corner duties in Williams' absence. Williams is scheduled to be an unrestricted free agent after the season.

Williams, who when healthy serves as the team's primary nickel corner, has appeared in just six games this season as he's dealt with hip, knee and ankle injuries.