Real Madrid playmaker Isco has been left out of Luis Enrique's squad for Spain's Euro 2020 qualifying double-header later this month.
Koke, Saul Niguez and Thiago Alcantara are also absent ahead of the games against Norway and Malta.
However, former Manchester City winger Jesus Navas is a surprise inclusion while Dani Carvajal, Lucas Vazquez, Diego Costa, Iago Aspas and Diego Llorente miss out through injury.
Isco has struggled for minutes at the Bernabeu under coach Santiago Solari, who this week was replaced by Zinedine Zidane.
Luis Enrique took over the national team following Spain's disappointing World Cup last summer but after a good start with wins over England and Croatia in the Nations League, failed to reach the tournament's final phase.
Spain host Norway at Mestalla Stadium in Valencia on March 23, then visits Malta three days later.