The Tennessee Titans might be in trouble this weekend ... 'cause Patrick Mahomes' jersey has made its way to The Holy One before the big AFC Championship Game!!!

It's becoming a trend for Pope Francis to receive NFL QB jerseys -- he received a custom Ravens jersey signed by Lamar Jackson back in December.

The Pontiff's collection just got a nice MVP addition ... with the bishop of the diocese of Kansas City-St. Joseph gifting it to him in Vatican City on Thursday.