The NFL Week 4 schedule starts with the injury-plagued Denver Broncos heading to Jersey to take on the Saquon Barkley-less Giants. It concludes with a pretty lopsided matchup between the Green Bay Packers and a struggling Atlanta Falcons team. 

In between, the Minnesota Vikings will take on the Houston Texans in a must-win game for each team while the Steelers head to Nashville to take on another undefeated team in that of the Titans.

Here’s a look at the NFL Week 4 schedule with game-by-game predictions. 

Updated: Sept. 27, 5:20 PM EST 

NFL Week 4 Thursday Night Football

Denver Broncos at New York Jets

Time/station: 8:20 PM EST, NBC

Broncos-Giants point spread: Broncos -2.0

The wide array of injuries for Denver should give New York a fighting chance here. Taking on a skill group headed by Jeff Driskel, Melvin Gordan and Jerry Jeudy is much different than going up against Drew Lock, Phillip Lindsay and Courtland Sutton, the latter two of whom are Pro Bowlers. 

As for the Jets, they have been downright miserable thus far on the young season. That included a blowout 31-13 Week 2 loss to an injury-plagued 49ers team. New York lacks an ability to be competitive, ruining Sam Darnold’s ability to progress under center in the process.

NFL Week 4 prediction: Broncos 27, Jets 17