The annual NFL Thanksgiving Day slate will pit the Buffalo Bills against the Detroit Lions, the New York Giants against the Dallas Cowboys, and the New England Patriots against the Minnesota Vikings. Check out all of our top NFL picks and predictions for Thanksgiving Day.

Our NFL betting experts offer up their top moneyline, against-the-spread, and Over/Under picks for the NFL's traditional three-game Thanksgiving Day slate. Check them out below, along with our top three-leg parlay, same-game parlays, and prop picks!

Click the links below to access our full NFL picks previews for every game on Thanksgiving Day.

Check out our top sites for Maryland sports betting.


Bills vs. Lions Picks

Spread: Lions +9.5 (-105 via PointsBet)
Over/Under: Over 53 (-110 via DraftKings Sportsbook)
Prop: Jamaal Williams anytime touchdown (-125 via DraftKings)