The 49ers used the No. 1 overall choice on quarterback Alex Smith in 2005. Smith retired Monday after 16 NFL seasons, the first eight spent in San Francisco. 

Smith went 38-36-1 with the 49ers, passing for 14,280 yards with 81 touchdowns and 63 interceptions. The 49ers traded Smith to the Chiefs after the 2012 season, and, in 2013, the quarterback earned his first of three Pro Bowls.