Scottie Pippen's estranged wife, Larsa Pippen, says she is NOT hooking up with NBA superstar Ben Simmons ... adamantly denying she was getting close to the hooper earlier this week.

There were reports Pippen and Kendall Jenner's recent ex-boyfriend were looking like a couple at The Highlight Room on Monday night ... with the non-couple leaving within minutes of each other that night.

The news would be a MAJOR deal in the Kardashian world since Larsa is BFFs with Kim and Kourtney. #SCANDALOUS!!

But, Larsa is having NONE of that talk ... saying she never even saw the 23-year-old Sixers point guard that night ... and would NEVER betray a family friend a la Jordyn Woods.