The White Sox are loading up for the Detroit Tigers.

With Gavin Floyd unavailable for his scheduled turn Friday because of a sore right elbow, Jake Peavy will skip the Orioles on Wednesday and face the Tigers in the crucial three-game series opener at Comerica Park.

"You want the guys you've been counting on — your best guys — going to take your best shot,'' manager Robin Ventura said.

Dylan Axelrod is on his way from Class AAA Charlotte and will start Wednesday against the Orioles, Ventura indicated. Francisco Liriano will start Saturday against red-hot Tigers right-hander Max Scherzer, and Chris Sale will oppose Justin Verlander in the series finale on Sunday night.