Just as their manager suggested it would the White Sox showed signs of life Wednesday after the nonwaiver trade deadline passed.

The Cleveland Indians just had more.

Carlos Santana led off the 10th inning with a game-winning solo home run as the White Sox dropped a 6-5 decision at Progressive Field. The homer came an inning after Cleveland scored twice off White Sox closer Addison Reed to extend the contest.

The Indians have won 10 of 12 meetings against the White Sox who dropped to 25 games below.500 for the first time since Sept. 11 1989.

“With a team like this that has been swinging it the way they have they have that edge you like to see and Reeder just didn’t get it done today” White Sox manager Robin Ventura said.

Pinch-hitter Jeff Keppinger’s two-run single with two outs in the ninth inning appeared to put the White Sox -- who played their first game since Jake Peavy was traded to Boston --- in the driver’s seat.