Seeking to rebound from their first loss of the season, the Rockets will begin their three game-road trip with a third of their rotation, including a pair of starters, out.

Forward Trevor Ariza was ruled out with a sprained left foot after he was stepped on during Monday's loss to the Grizzlies. Center Nene is doubtful with a left Achilles injury, though Rockets coach Mike D'Antoni spoke of playing without him as if there is no chance he could be back to play in Philadelphia on Wednesday. Guard Chris Paul is out with a bruised left knee.

"Last year was pretty smooth sailing, a little smoother than a (typical) season," D'Antoni said. "This year, we have some rough spots. We have some injuries to deal with. We got some play to work out. But we'll battle through this and get back on track."

The Rockets initially considered Ariza day-to-day, but believed they would know more about a timetable after his examinations on Tuesday.