Alejandro De Aza hit an RBI single off Tigers reliever Phil Coke in the 11th inning to give the White Sox a 4-3 victory over the Tigers at U.S. Cellular Field on Tuesday night.

De Aza’s second walk-off hit in a week drove in Sox right fielder Avisail Garcia who walked to lead off the inning and advanced on a Jeff Keppinger sacrifice bunt and Jordan Danks groundout. De Aza had a two-run triple in the 12th inning against the Yankees on Aug. 7.

“To make contact” De Aza said of his goal when stepping to the plate. “Make good solid contact because I know the infield was in and I was just trying to put the ball in play.”

Closer Addison Reed (5-1) earned his first win since July 4 after pitching the final two innings giving up two hits. Jeremy Bonderman (2-4) got the loss after loading the bases in the 11th before Coke entered.

Sox left-handed starter Hector Santiago went five innings despite suffering from a swollen face due to an infected tooth. He said he went to the dentist Monday morning because of swelling and the dentist performed a root canal.

He said he had a fever Tuesday morning but took several cold showers to get ready for his start at night. He gave up six hits and one earned run walked four and struck out three.

The Tigers took a 1-0 lead off Santiago in the second inning when Omar Infante's single drove in Prince Fielder.

“Every time I threw a pitch I was kind of grimacing a little bit” Santiago said. “It was shooting pain. That wasn’t the problem. It was more of being weak in the legs. I was in bed for 20 straight hours yesterday.”

The Sox came back when Garcia playing against his former team hit a triple down the right-field line off Tigers starter Max Scherzer in the fourth inning to drive in Gordon Beckham and Alexei Ramirez. He then scored on a throwing error to third by Infante to put the Sox ahead 3-1.