Mother Nature has joined the list of folks the Yankees can’t beat.

Last night at Yankee Stadium, rain delayed the start of the Red Sox game for 45 minutes even though a drop never fell.

In the top of the sixth, it was halted for 37 minutes. Four minutes after it was re-started at 11:21, it was stopped again. Finally, after a 45-minute delay, in which a bolt of lightning and a very loud thunder clap sent fear throughout the Stadium, it was called.

When it ended, the hitting-challenged Yankees drowned in a 3-0 loss to the Red Sox in 5 1/2 innings that drew 43,613 customers.

“It’s frustrating. It looked like [the umpires] were playing the percentages because it looked like we were going to get hit pretty hard around 8:15 and we didn’t,’’ Joe Girardi. “Then it looked like we would be OK until 11:30-11:45. It came earlier than we would have liked.’’

The rain chased starters Clay Buchholz and Hiroki Kuroda, and Buchholz’ exit seemed to give the Yankees a chance after the right-hander dominated them across five innings in which they didn’t get a runner past first.

However, the rain caused the game to be called so the Yankees never got a chance to hit against the Red Sox bullpen.

After getting swept in four Subway Series games by the Mets that extended the season-long losing streak to five, the Yankees opened a three-game series with their AL East blood rivals with a win Friday night fueled by a solid pitching effort by CC Sabathia.