Ending their latest losing streak was just out of reach for the Boston Red Sox.

The slide reached six straight in painful fashion Friday night as the Seattle Mariners rallied for five runs with two outs in the ninth inning to beat Boston 5-3.

"This was pretty tough. If that's not the tale of how this season has gone so far, I don't know what is," shortstop Brock Holt said.

Austin Jackson hit a bases-loaded double with two outs in the ninth to pull the Mariners within 3-2, then Dustin Ackley followed with bloop single that Holt couldn't quite reach on a diving attempt in shallow left. Two more runs scored and the 3-0 lead Boston held with two outs in the ninth was now a 4-3 deficit.

"Unfortunately Ackley finds kind of the Bermuda Triangle out there to drive in the two," Boston manager John Farrell said.

Red Sox closer Koji Uehara (5-4) gave up all five runs on five hits in the ninth as the World Series champion Red Sox fell to a season-low 16 games below .500.

Seattle ended a nine-game losing streak at Fenway that began in May 2011.

The Mariners had managed only two hits through the first eight innings, then got five against Uehara and extended Boston's losing streak to six.