"Starting RB Ryan Grant has been ruled out of the Buffalo game with the ankle injury, which McCarthy described as serious. More tests are being conducted. "Well, it's a significant injury to the ankle and the ligament involved in the ankle, which has now required more testing, and we'll continue to process all the information throughout the day." He doesn't yet know if the injury will require surgery.

McCarthy said he will not make a deicision about a potential roster move at the running back position -- like possibly promoting James Johnson from the practice squad -- until he knows the full scope of Grant's injury."