Pirates' top prospect Gerrit Cole will make his major league debut Tuesday at PNC Park against the San Francisco Giants, the team officially announced this afternoon.

Cole will face two-time Cy Young winner Tim Lincecum, and the defending World Series champions at 7:05 p.m.

The Pirates are expected to activate Cole on Tuesday and will need to make corresponding roster moves to make room on the 25- and 40-man rosters.

Cole, 22, was the first overall draft pick in 2011 and went 5-3 with a 2.91 ERA in 12 starts for Class AAA Indianapolis this season. He made 38 minor league starts over the past two seasons, posting a 2.84 ERA between stops in Classes AAA, AA and A.