The Patriots listed defensive end Trey Flowers as questionable on Friday, but they didn’t wait until Sunday to make a final decision on his status.

The team announced on Saturday night that Flowers has been ruled out for their matchup with the Bills in Buffalo. Flowers was limited in practice during the week due to a rib injury.

Flowers has played on 88 percent of the defensive snaps for New England this season and leads the team with six sacks, so his absence will be a significant one on the defensive line.