The Midwest Regional has two of the most intriguing Sweet 16 matchups. Before you get your bets down Friday, make sure you cruise these betting news and notes for the Midwest side of the bracket.

No. 2 Michigan Wolverines vs. No. 11 Tennessee Volunteers (-2.5, 134)

Senior Jordan Morgan came up big, playing 35 minutes and earning a double-double (15 points, 10 rebounds) in the win over a very good rebounding Texas team. The 6-foot-8 forward averages just six points and five boards per game on the year, but has been solid in the NCAA with 25 points and 20 rebounds in the past two games. Morgan has a tough matchup in Jarnell Stokes, who had 18 rebounds in Tennessee's win over Mercer. But the Wolverines should feel confident that they have the secret to beating a tough interior team after handling the Longhorns.

Tennessee looks to continue its reputation as an under-seeded team. The Volunteers were ranked 11th in Ken Pomeroy's ratings system before being handed a No. 11 play-in seed. That hasn't deterred them from making a tournament run to the point where Pomeroy's rankings have the Vols as the sixth-ranked team in the country after the opening weekend, with Michigan sitting tenth. According to Pomeroy and his ratings system, this game may just be in the Vols’ favor.

No. 4 Louisville Cardinals vs. No. 8 Kentucky Wildcats (-4, 138.5)

The Cardinals are a poor 15-31 SU against their in-state rivals and 5-9 in the Rick Pitino Era in Louisville. Luckily for the Cardinals they are red hot, winning 14 of their last 15 games (10-5 ATS) down the stretch and hold the edge in experience over a young UK squad with seniors Russ Smith and Luke Hancock anchoring the team. However, Louisville wasn't tested often this year, boasting the second weakest strength of schedule among the Sweet 16 teams (75th in the country).