The final four teams in the East Regional do battle for a spot in the Elite Eight. Before you bet on Friday's games, brush up on these East Region betting news and notes:

No. 1 Virginia Cavaliers vs. No. 4 Michigan State Spartans (-1.5, 127)

The Virginia Cavaliers’ pack-line defense, designed to protect driving lanes and keep opponents out of the key, gave Memphis fits Sunday. The Tigers shot just 40 percent from the field and scored 18 points below their season average. The defense’s one weakness though is on the perimeter and contesting longer-range shots. The Spartans just so happen to be the country’s 14th best 3-point shooting team, knocking them down at a 39.3 percent clip.

Despite not facing the Cavaliers this year, the East Region’s No. 1 seed doesn’t hold much mystery for Tom Izzo. The Michigan State boss coached at camps run by Cavs’ head coach Tony Bennett’s father, Dick, who was a coach at Wisconsin, against Izzo in the early 2000s. Further to this, Tony was an assistant to his father on those Badger teams.

“This is as home as it gets for me, as far as knowing who I’m playing,” Izzo said, “knowing the style they play.”

No. 3 Iowa State Cyclones vs. No. 7 Connecticut Huskies (+1.5, 147)

The Cyclones connected on 12 of 26 3-point attempts versus North Carolina, numbers that are above their season averages of 8.4 made and 23.5 attempts. Connecticut doesn’t do a great job running teams off the 3-point line, allowing opponents over 18 attempts per game - a number that was bested by Villanova, who hoisted 31 from behind the arc in the round-of-32.