The middle of the Red Sox order performed Wednesday night as if it was already the middle of the season.

David Ortiz and Mike Napoli each supplied two-run homers and Napoli later added a two-run single, sending the Red Sox to a 6-2 victory over the Baltimore Orioles.

Ortiz collected his first homer of the season -- and No. 432 of his career, passing Cal Ripken Jr. -- in the third, scoring Dustin Pedroia (single) ahead of him.

In the sixth, Napoli crushed a pitch from Orioles' starter Ubaldo Jimenez to straightaway center. It came on an 0-and-2 pitch, marking
the first time Napoli had hit one out on that count since 2012.

In the seventh, with Jimenez out of the game, the Orioles elected to walk Ortiz intentionally, loading the bases with no out for Napoli. Napoli lined a single to center, scoring two runs and salting the game away.

Pedroia enjoyed a four-hit game -- all singles -- for the first time since 2012.

John Lackey turned in a strong six innings, with his only mistake coming in the fourth. He walked Chris Davis on four pitches, then tried to go up and away on Nelson Cruz, who launched it to the opposite field for a two-run shot.

Lackey allowed just three hits through six.

Edward Mujica, Junichi Tazawa and Koji Uehara all pitched scoreless innings, with the latter appearing in a rare non-save situation.