Will Middlebrooks homered three times and doubled as the Boston Red Sox hit Toronto starter R.A. Dickey hard early, then cruised to a lopsided 13-0 victory over the Blue Jays on Sunday afternoon.

Middlebrooks' two-run shot helped anchor a five-run first off knuckleballer Dickey as Boston (4-2) earned the rubber game of the series before 41,168 spectators at Rogers Centre, many resorting to a "Go Leafs Go," chant late in the contest. Middlebrooks added to their angst with solo blasts in the fifth and seventh innings for his first career three-homer contest, giving him four this season.

Daniel Nava, Jacoby Ellsbury and Mike Napoli also homered and drove in four runs for Boston, which had just two hits in a 5-0 loss to Toronto on Saturday.

But the Red Sox tagged right-hander Dickey (0-2) for eight runs -- seven earned -- on 10 hits (including two homers) over 4 2/3 innings. Dickey fanned five while walking two and often drawing his share of boos from the stands.

Dickey, the 2012 NL Cy Young winner, allowed five hits and four runs -- three earned -- four walks and four strikeouts over six innings in his Toronto debut, a 4-1 home loss to Cleveland on Tuesday.

Sunday's thumping capped a less than stellar season-opening six-game homestand for Toronto (2-4), which entered the campaign with high expectations following the off-season acquisitions of Dickey, infielder Jose Reyes, pitcher Mark Buehrle, slugger Melky Cabrera and return of manager John Gibbons. But after having an off-day Monday, the Jays head out of town for a six-game road trip, starting Tuesday in Detroit.

Left-hander Jon Lester (2-0) allowed five hits over seven scoreless innings with six strikeouts and one hit batter to improve to 12-7 in 23 career starts against Toronto. He came into Sunday's game having held the Jays to a .204 batting average all-time and never was threatened in this one.

Right-hander Clayton Mortensen preserved the shutout, allowing two hits while fanning four over the final two innings.

Boston exploded in the first as Dickey surrendered hits to the first five batters he faced. Ellsbury led off with a double and scored on Dustin Pedroia's single. Pedroia and Shane Victorino came home on Napoli's two-run double before Middlebrooks belted a two-run homer to make it 5-0.

Dickey surrendered five first-inning runs all of last season with the New York Mets.