The Blue Jays' wobbly start took a grim turn Friday night when an ankle injury drove shortstop Jose Reyes from the game.

Reyes, attempting to steal second in the sixth inning in what turned out to be an 8-4 victory over Kansas City, rolled his left ankle on his trailing leg as he made an awkward slide into second. The Jays shortstop was writhing in agony after the slide and after several minutes was taken from the field on a cart.

The Jays announced he had suffered a left ankle sprain and was taken to hospital for a MRI.

Reyes was one of general manager Alex Anthopoulos' prized acquisitions in the off-season megadeal with the Miami Marlins.

Reyes had been one of the few players that was living up to his all-star billing as he left with a nine-game hitting streak and was hitting .395 overall (15-for-38). He also had five stolen bases.

Just before he stole second and injured his ankle, Reyes singled to centre to drive in two runs and send the Jays into an 8-4 lead.

With Reyes taken out of the game and Maicer Izturis unable to play after fouling a ball off his foot on Thursday, the Jays were forced to move right fielder Jose Bautista to third, switch Emilio Bonifacio from second to short and move third baseman Mark DeRosa to second.

The Jays will need to call up a middle infielder for Saturday's game.

In 2012 the Jays suffered a high number of injuries, especially to their pitching staff, and the hope this season was that the injury bug would avoid them in 2013.

Friday it took a giant bite.

Reyes has suffered a variety of injuries in three of the past four seasons (calf and hamstring issues) and one of the concerns was how he would hold up on the turf at Rogers Centre.