"The Giants likely are going to have to take to the air today against a 49ers defense that is the NFL's best at stopping the run.

Will Eli Manning have enough targets to throw to? That's a legitimate question after Mario Manningham yesterday unexpectedly was added to the injury report with a knee issue.

Manningham is listed as questionable for the game, though the other starting receiver, Hakeem Nicks, is expected to play barring a setback after missing last week's victory in New England with a hamstring injury."