The timing really couldn’t have been better for the Houston Astros to resurface on the A’s schedule.

With a three-game sweep at the hands of Texas still fresh in their memories, the A’s arrived at Minute Maid Park and administered a 10-1 smackdown on the Astros in the opener of a four-game series.

Josh Donaldson hit a pair of two-run home runs in a game that also featured a renewal of bad blood between the teams over an incident that happened last weekend in Oakland. Houston reliever Paul Clemens was ejected in the top of the seventh for hitting Jed Lowrie with a pitch, apparently continued retaliation from Friday’s game at the Coliseum, when Lowrie bunted with Oakland leading 7-0 and Clemens threw a pitch between his legs. Astros manager Bo Porter came out of the dugout and gestured at Lowrie after that incident, and Lowrie was critical of Porter in his postgame comments that night.

Another development to monitor closely: A’s left fielder Yoenis Cespedes left the game in the top of the seventh with an apparent leg or foot injury after legging out an infield single. He was replaced by pinch runner Josh Reddick, and his status wasn’t immediately known.

The A’s finished with 14 hits to begin this 10-game road trip on a high note.