San Francisco 49ers right guard Brandon Fusco had almost no chance.

With the 49ers trailing the Los Angeles Rams 41-39 during Week 3 and facing fourth-and-20 with under two minutes remaining, Fusco had the responsibility of blocking defensive tackle Aaron Donald one-on-one.

Donald used his power to get Fusco off balance and then switched to a speed move to motor by him and sack quarterback Brian Hoyer for a loss of eight yards.

His sack ended that game, and Donald is more than capable of disrupting what the Jaguars want to do on offense Sunday at EverBank Field.

“He has rare speed at that three-technique position,” said right guard A.J. Cann. “That goes along with his power and that generates a lot of physical strength.”

And a lot of problems for opposing offensive lines. Donald appears to be rounding into form after he missed all of the preseason in a contract holdout.

“You really [see] him getting more comfortable and getting back into football mode,” Rams coach Sean McVay said. “The last few weeks, I think he’s played like one of the best defensive tackles in the league, which we’ve known he’s been for the last handful of years.”

Donald played 53 of 68 defensive snaps last week against Seattle. On the Seahawks’ six-play opening possession, Donald came from quarterback Russell Wilson’s right three times, from his left twice and lined up over the center once.