The waiting game resumes for reliever Jesse Crain and the White Sox.

The reliever suffered a setback in his comeback from a right shoulder injury and that set back the ball club’s attempts to trade him before Wednesday’s non-waiver trading deadline.

The shoulder didn’t feel well after he played catch before Thursday’s 7-4 victory over the Tigers so Crain will take a break from his throwing program. That virtually assures he can’t rejoin the Sox soon enough for several interested teams to evaluate him before the deadline.

The Braves were among the teams with the strongest interest in Crain according to several sources.

Sox pitching coach Don Cooper emphasized the main concern is getting Crain’s right shoulder healthy and described Thursday’s developments as a “slight setback.’’ But it’s a bigger blow to the Sox in their attempts to maximize the value for Crain an All-Star who hasn’t pitched since June 29 and can become a free agent after this season.