Sabres fans are holding their collective breath in the wake of what could be a serious injury to star sophomore Jack Eichel.

At Wednesday morning’s practice — ahead of Thursday’s season-opener against Montreal — Eichel rolled back on what appeared to be his left ankle, screamed out in pain and was helped off the ice.

Losing Eichel for any length of time would be a huge void to fill. As a rookie, he led the team with 24 goals last season and finished second in points, with 56.