Commissioner Bud Selig is proud of how far baseball’s drug-testing procedures have come, but he said Saturday he thinks it’s time for the sport to toughen up its penalties for performance-enhancing drugs.

Though Major League Baseball remains at the forefront of testing — earlier this year it became the first professional sports league to blood-test randomly for human-growth hormone — Selig is discouraged there are still players willing to risk getting caught.

As it stands, players who test positive for performance-enhancing drugs are given 50-game suspensions for a first offense, 100 games for a second and are banned from the sport for life for a third positive. Selig wants more.

“We’ve made meaningful adjustments to our testing,” he said, “and the time has come to make meaningful adjustments to our penalties.”

Selig said he was inspired to push for tougher penalties in large part because of last year’s positive test by Giants star Melky Cabrera and the recent situation involving Biogenesis of America, the Florida-based clinic that reportedly has been funneling performance-enhancing drugs to several high-profile big-leaguers.

“Apparently the penalties haven’t deterred some people,” he said.

Selig said he was encouraged by the recent remarks he’s read from both players and union head Michael Weiner. He referred to comments made by Colorado outfielder Michael Cuddyer, saying they “articulated my views beautifully.”

“The game is getting clean, but when we continue to see stuff (like Biogenesis) pop up, it looks like we are not,” Cuddyer told the Denver Post last month. “It would definitely take clean players stepping up and asking for more (discipline). I firmly believe there's more clean players than not. If we are serious about this, we should do it.”