Following a cross-country flight, Charlie Manuel was ill on Monday afternoon at Petco Park. He didn’t feel much better Monday evening, when he watched his team suffer what was arguably its most sick-inducing loss of the season.

But a night after Cliff Lee took a shutout into the ninth inning only to see Jonathan Papelbon blow his fourth save in eight days, Manuel and Co. received a healthy shot of adrenaline in an attempt to reboot a free-falling season.

A month removed from the start of his home run binge, Domonic Brown launched a three-run home run to erase an early deficit and guide the Phillies to a 6-2 victory on Tuesday night.

“That’s the great thing about having a lot of veteran leadership in the clubhouse – they keep us nice and upbeat,” Brown said of the Phils rebounding from the previous night’s crushing loss. “I know I’m one of the guys that wants to start thinking, but I watch Jimmy (Rollins) and (Ryan) Howard and (Chase) Utley and those guys and just go out and worry about the next game. That’s really all you can do.”

After Kyle Kendrick allowed two runs in the bottom of the second, Brown ripped a two-out, three-run home run off of Padres starter Jason Marquis in the next half inning. The home run was Brown’s 20th of the season.

Brown is the first Phillies player to reach 20 home runs before July since both Raul Ibanez (22) and Ryan Howard (20) did so in 2009.

After hitting 11 home runs in 57 at-bats of a 15-game stretch from May 25 to June 8, Brown hit his first home run in 15 days and 57 at-bats on Tuesday. Brown hit .192 (10-for-52) with a .252 OBP, .509 OPS and 15 strikeouts in his 14 games in between home runs.

“How long?” Brown interrupted a reporter who was letting him know it had been some time since his last home run. “I’m just out there playing, having fun. It’d been a while.”