After struggling against a good pitcher they were unfamiliar with Wednesday at Pittsburgh, the Braves on Thursday faced a Reds pitcher who had nothing in common with the Pirates’ Gerrit Cole other than being the same age.

David Holmberg never stood a chance.

The Braves chased the Reds left-hander with a five-run third inning, while Julio Teheran pitched six innings of four-hit ball in an 8-0 Atlanta win to open a four-game series at Great American Ball Park.

It was the sixth win in seven games for the Braves, who improved to 3-1 on a 10-game road trip.

Andrelton Simmons homered in the second inning and Justin Upton had two hits and three RBIs for the Braves, including a two-run single in the third inning when they took a 6-0 lead.

The first four in Atlanta’s batting order reached base 11 times and accounted for six runs and four RBIs: Jason Heyward had two singles and a walk; Phil Gosselin had two hits including a double, and Freddie Freeman walked and was twice hit by pitches.

Upton, the cleanup hitter, added a sacrifice fly and a walk to go with his two hits, raising his average to .400 (16-for-40) with four homers and 18 RBIs during a 12-game hitting streak.

Teheran (12-9) kept his focus through some marathon innings by Braves batters. He walked none, struck out three, and didn’t give up an extra-base hit until Brandon Phillips’ two-out double in the fourth, the final hit he allowed. Teheran threw 61 strikes in 87 pitches, and the game was nearly at the 2 ½-hour point when he left after six innings with an 8-0 lead.

Holmberg (0-1) entered with a 16.88 ERA and .500 opponents’ average in one start this season – the second game of a doubleheader against the Cubs — and managed to raise that ERA to 18.56.

In three career starts, the 23-year-old has a 14.00 ERA with 18 hits, 14 runs, four homers and 10 walks allowed in nine innings. He hasn’t made it through the third inning of either start this season.