A record eight-run first inning supplied the Diamondbacks with all the offense they needed as they captured the series over the San Diego Padres on Wednesday in front of 22,233 at Chase Field.

"That kind of set the tone for us," manager Kirk Gibson said.

The Diamondbacks put up two runs on four hits before there was a single out and chased Padres starter Tim Stauffer (2-1) from the game when it was 5-0 after only a third of an inning. CF A.J. Pollock and RF Gerardo Parra led the charge, accounting for a pair of singles, two doubles and three RBIs. The eight runs scored set a franchise record for the first inning, and the team's eight hits tied a team-high. 3B Martin Prado added a two-run homer in the second to make it 10-0.

The Padres erased the shutout in the fourth when LF Tommy Medica reached with a triple and later scored, and they added three unearned runs in the next inning to cut their deficit to six. 1B Paul Goldschmidt made it 12-4 in the seventh with a two-run homer off the video board in center field — a 470-foot shot, according to ESPN Stats and Info. He finished with three hits and three RBIs. Pollock also had three hits, and SS Chris Owings was responsible for four of the team's 17 hits — the first four-hit night of his career.

For the Padres, Medica finished a single shy of the cycle after his homer in the eighth. Later in that inning, LHP Joe Thatcher inherited a bases loaded jam from RHP Randall Delgado and walked in a run after hitting Carlos Quentin with a pitch.

With the win after five innings of work, right-hander Chase Anderson became the first Diamondbacks rookie to win his first three starts. Despite leaving the game 10-4, he was tagged with only one earned run. In his past two starts – Anderson's previous appearance last Friday was called in the fourth inning due to rain – the Diamondbacks have amassed 30 runs. He was at the helm when the Diamondbacks pounded the Dodgers 18-7 May 17.

"Shoot, what was it last game? 18 runs," Anderson said. "Twelve tonight. That's a pitchers dream. It definitely makes it a lot easier to go out there and relax."