Jose Abreu stepped to the plate in the eighth inning Wednesday at O.co Coliseum with two runners on and the Sox in need of some runs to salvage one game in their three-game series against the Athletics.

Conor Gillaspie, who was on first after he and Gordon Beckham hit back-to-back singles, wasn’t surprised with what came next.

“At this point, no,” Gillaspie said. “He has ridiculous power.”

Playing on a sore left ankle that has pushed him to designated hitter the last six games, Abreu launched a three-run homer to left field off A’s reliever Luke Gregerson that bounced off the front of the upper deck. His 15th home run of the season gave the Sox a 4-2 victory over the A’s and broke a four-game losing streak.

“You get in those situations and you’re pretty glad he’s up,” Sox manager Robin Ventura said. “That’s what he means to us. You always feel you’re in a good spot if he’s up with some guys on.”

Abreu said his ankle feels fine, but Ventura may give him Friday off in the series opener against the Astros. All of the runs were scored on homers.

Beckham hit the first pitch of the game from A’s left-hander Tommy Milone over the left-field wall. A’s designated hitter John Jaso answered Beckham promptly, sending Sox right-hander Andre Rienzo’s third pitch of the game over the wall in right-center field to tie the game. And A’s third baseman Josh Donaldson added a home run to right in the fourth.

Rienzo matched a season high by pitching 6 1/3 innings. The home runs were the only A’s hits and runs he allowed, both season lows.